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Document Type

Original Article

Abstract

Background: One of the most prevalent conditions without a proven long-term treatment is chronic rhinosinusitis (CRS). There are two phenotypes of chronic rhinosinusitis (CRS): chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP). Immunomodulation is thought to be a function of vitamin D (VD), particularly in allergic disorders. Objective: This investigation was done to assess the link between blood VD3 levels and CRS, whether it had polyps or not. Patients and methods: 90 people from both sexes participated in this study. Adults were divided into three categories and given the diagnosis of sinusitis by the American Academy of Otolaryngology Head & Neck Surgery: CRSsNP (30 subjects), CRSwNP (30 subjects), and control group (30 subjects). Using an ELISA (enzyme-linked immunosorbent assay), VD levels were measured (ELISA). Results: The serum 25 (OH) D level varied between the CRSsNP Group (23.10±7.40), CRSwNP Group (22.20±8.12), and Control Group (26.22±8.25). Regarding VD3, there was no discernible difference between the studied groups. Age-related differences across the groups were statistically significant, with CRSwNP being more prevalent in the older age group (55.07±5.78). There was no discernible difference in symptomatology or sex. Conclusions: Chronic rhinosinusitis, whether it had polyps or not, did not correlate with serum vitamin D3 levels. This indicates that low levels of serum 25 (OH) D are not a potential risk factor for CRS in adult patients.

Keywords

1-α-hydroxylase; HSNEC; Nasal polyps; Rhinosinusitis; Vitamin D3

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