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Corresponding Author

Bothina Abd El Naby Ibrahim Ageeba

Document Type

Original Article

Abstract

Background: Alopecia areata (AA) is a widespread, non-scarring skin illness, triggered by T-cell-mediated autoimmune responses targeting hair follicles at anagen-stage. AA is a relatively frequent disease with a worldwide incidence of 1%-2%. However, AA is among the most prevalent autoimmune disorders. In general, there is no sex preference. It often affects children and young people more frequently. The scalp is the place that is most frequently impacted, but any area that bears hair might also be affected. Severe forms can be present as alopecia totalis or alopecia universalis. This study aimed to compare the effectiveness of intralesional triamcinolone acetonide versus microneedling with triamcinolone acetonide for alopecia areata treatment. Patients and Methods: 50 patients presenting with localized AA will be included in this comparative study, all of whom were recruited in the Al-Azhar University Hospitals' Dermatology Outpatient Clinic. Results: The collected data was tallied and statistically analyzed. The findings revealed a statistically significant reduction of the SALT score and all dystrophic hair markers of AA by dermoscopy at the end of the study versus baseline in both groups. The difference between the microneedling group and the intralesional group concerning clinical response was statistically insignificant. Conclusion: Microneedling is an effective collagen induction therapy in treating AA, especially when combined with Triamcinolone acetonide, as it provides a comparatively inexpensive, safe, less painful, less invasive tool with no serious complications.

Keywords

Microneedling; Triamcinolone acetonide; Intralesional; Alopecia Areata.

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