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Corresponding Author

Ahmad F. Arbaeen

Document Type

Original Article

Abstract

Background: Sickle cell disease is an autosomal recessive disease characterized by an aberrant production of hemoglobin S (HbS). The disease's presentation and severity varied substantially between people from various socioeconomic backgrounds and geographical regions. The clinical picture includes hemolytic anemia, vascular occlusion events, acute and persistent pain, and varied organ damage. Objective: To investigate the clinical and hematological characteristics of adult sickle cell disease patients. Methodology: The study was conducted utilizing outpatient and inpatient data obtained retrospectively from a specialist hospital in Makkah city from January 2019 to December 2019. This study collected clinical and hematological data from all patients of sickle cell anemia (SCA) validated by high performance liquid chromatography (HPLC) between the ages of 18 and 50. The data was gathered from the laboratory database and contains demographic and hematological findings of CBCs performed on a fully automated hematology analyzer, as well as HPLC results for percentages of variant hemoglobins within the sickle cell anemia group. This study comprised a total of 130 participants with sickle cell anemia. All of the above patients' clinical findings were documented from the hospital archives. Results: The mean age for all the patients was 30.5±11.1 years. Pearson correlation for male patients showed significant positive correlations between hemoglobin-S and leucocytes (r= 0.503, P

Keywords

Sickle cell disease; hemoglobin; Pain crises.

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