Relation Between Adropin Levels and Hyperhomocysteinemia in Patients with Coronary Artery Disease

Authors

Bassem Mohamed Abdel Hady, Cardiology Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt
Ola Hassan Abd Elaziz, Cardiology Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt
Inass Hassan Ahmad, Endocrinology Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, EgyptFollow
Hala Naguib Mohamed, Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt
Marwa khairy Abd Elwahab, Clinical Pathology Department, Alzahraa University Hospital, Abbasiya neighbourhood, Cairo, Egypt

Corresponding Author

Inass Hassan Ahmad

Document Type

Original Article

Abstract

Background and aim: Homocysteine and adropin effects on endothelial function are antagonistic. The current study aimed to evaluate the association between serum levels of adropin and homocysteine and the severity of coronary artery disease (CAD) . Patients and methods: This cross-sectional study included 86 patients submitted to coronary angiography with ≥ 50% stenosis in one or more coronary arteries. Serum Adropin and homocysteine levels were estimated. The anatomical synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score was utilized to assess the severity of CAD. Results: According to serum homocysteine levels, they were classified into patients with normal homocysteine levels (GI; n=54) and patients with hyperhomocysteinemia (GII; n=32). Comparison between the studied groups regarding clinical and laboratory findings revealed that GI patients had significantly shorter duration of diabetes (3.8 ± 5.3 versus 8.2 ± 7.5 years, p=0.009), higher serum triglycerides levels (204.7 ± 99.6 versus 142.9 ± 55.6 mg/dL, p=0.002), lower HbA1c levels (7.2 ± 1.6 versus 8.2 ± 2.0%; p = 0.013) and significantly higher adropin levels (7.4 ± 2.5 versus 1.6 ±1.0, p

Keywords

Adropin, Homocysteine, coronary artery disease, coronary angiography, and SYNTAX score.

How to Cite This Article

Hady, Bassem Mohamed Abdel; Elaziz, Ola Hassan Abd; Ahmad, Inass Hassan; Mohamed, Hala Naguib; and Elwahab, Marwa khairy Abd (2023) "Relation Between Adropin Levels and Hyperhomocysteinemia in Patients with Coronary Artery Disease," Al-Azhar International Medical Journal: Vol. 4: Iss. 2, Article 24.
DOI: https://doi.org/10.58675/2682-339X.1679