Clinical significance of urinary tumor necrosis factor-like weak inducer of apoptosis in lupus nephritis

Authors

Elsayed Mohamed Rashed, Department of Internal Medicine and Nephrology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt
Hani Ismail Hamed, Department of Internal Medicine and Nephrology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt
Abdelsalam Fathy Abdelsalam, Department of Clinical Pathology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt.
Amr Atef Ali Aref, Department of Internal Medicine and Nephrology, Faculty of Medicine for boys, Al-Azhar University, Cairo, EgyptFollow

Document Type

Original Article

Abstract

Background: TWEAK is a cytokine that is both pleiotropic and multifunctional. It is a member of the tumor necrosis factor (TNF) superfamily, which regulates the pathways that lead to inflammation. TWEAK is a critical component in the development of lupus nephritis (LN) because it is responsible for the death of renal mesangial cells and tubular epithelial cells. This death occurs as a result of several intracellular signal transduction cascades. Aim and Objectives: to better understand how Tweak is related to lupus nephritis, and to look at whether or not Tweak levels may be used as a marker of LN existence and activity. Patients & methods: The Case-Control Study was done on 40 cases with biopsy-proven LN at the Nephrology Department of Al Hussein University Hospital among April and September of 2022. Results: All the cases showed positive ANA and Anti dsDNA antibodies regarding laporatory data. The urinary level of tweak was statistically significantly higher in the lupus nephritis cases matched to the control group. A statistically significant +ve relationship among urinary tweak with serum creatinine and Albumin/creatinine ratio a statistically significant negative correlation between urinary tweak with C3. The best cutoff point of Urinary tweak to identify cases with lupus nephritis was > 6.83 Pg/ml. Conclusion: In cases when the diagnosis of a flare is uncertain, urinary TWEAK may be a useful biological tool. The treatment requirements and prognosis of individuals with lupus nephritis (LN) can be better determined if this can be refined for routine clinical usage.

Keywords

urinary tumor necrosis factor-like; apoptosis; lupus nephritis.

Subject Area

Internal Medicine

How to Cite This Article

Rashed, Elsayed Mohamed; Hamed, Hani Ismail; Abdelsalam, Abdelsalam Fathy; and Aref, Amr Atef Ali (2023) "Clinical significance of urinary tumor necrosis factor-like weak inducer of apoptosis in lupus nephritis," Al-Azhar International Medical Journal: Vol. 4: Iss. 12, Article 21.
DOI: https://doi.org/10.58675/2682-339X.2160