Abstract
Background: Multiple factors contribute to acne vulgaris, a disorder of the pilosebaceous units. mTOR pathway dysregulation is associated with many inflammatory conditions. Aim of the study: was to assess mTOR gene expression as a prognostic molecular marker for acne vulgaris severity or recurrence. Patients and Methods: This study was a case-control that consisted of fifty persons with acne vulgaris & fifty age also sex-matched healthy persons. Patients were recruited from the Dermatology Department, Suez Canal University hospital. mTOR gene expression was conducted using polymerase chain reaction (PCR) at the Oncology Diagnostic & Research Unit, Faculty of Medicine, Suez Canal University. Results: In the patient group, there were 34 (68%) with mild acne, 15 (30%) with moderate, and only one (2%) with severe acne. The mean mTOR expression in the patients’ group was statistically significantly greater by fivefold than in the control groups. There was a positive nonsignificant association amongst mTOR expression & the duration of the disease in Acne vulgaris patients (r = 0.253, p > 0.05). Conclusion: mTOR is higher expressed in acne patients than in control. mTOR can be employed as a biomarker for acne vulgaris prognosis and response to treatment.
Article Type
Original Article
Keywords
Acne, Acne Vulgaris, mTOR, PCR, Gene expression
Subject Area
Dermatology
How to Cite This Article
El-Fadeal, Noha M. Abd; Abdelhay, Nesma Ibrahim; Ismail, Nader Ali; and Nada, Hesham A
(2023)
"Elevated Mammalian Target of Rapamycin (mTOR) Gene Expression in Acne Vulgaris patients,"
Al-Azhar International Medical Journal: Vol. 4:
Iss.
12, Article 19.
DOI: https://doi.org/10.58675/2682-339X.2166
