Effect of Metformin and Myo-inositol in Patients with Polycystic Ovary Syndrome

Authors

Hanaa Fathi Abo Ria, Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.
Hanan Abd El-Monem Mohammed, Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.
Hoda Ismail Sayed Hemida, Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.Follow

Document Type

Original Article

Abstract

Background: Polycystic Ovary Syndrome (PCOS), also known as Stein-Leventhal syndrome, is a reproductive hormone condition. It causes irregular ovulation, nonexistent periods, insulin resistance, and androgenic hormone overproduction. Hormonal imbalances may cause extra hair growth, acne, hair loss, and greasy skin. If you suspect PCOS, visit a doctor. It may have a major influence on your health.

Aim: To determine the adjuvant effect of metformin & myo-inositol in polycystic ovary syndrome patients.

Methods: This research was performed on three subgroups of 100 women with PCO (according to the Rotterdam criteria, ESHRE/ASRM 2004) Group I (50 women): who received metformin (500 mg) + (2 gm myo-inositol) in the evening for 3 months.Group II (50 women): obtained metformin 500 mg (cidophage 500 mg) 3 times daily for 3 months. All females involved in the research were submitted to: Full history Taking (Personal, Medical, Menstrual and General history) and Physical examination.

Result: There was no statistically significant distinction in the baseline characteristics of both groups. Transvaginal Ultrasonography "Ovarian size" post-treatment showed a statistically significant distinction among both Groups in terms of normal ovarian size. The variance in pregnancy rates among the 2 groups was statistically highly significant. Also there was a statistical significant correlation among pregnancy rates according to transvaginal ultrasound regarding ovarian size in all patients.

Conclusion: We found that combination of Metformin with Myo-inositol give better results in Polycystic Ovary Syndrome than metformin only.

Keywords

metformin; myo-inositol; PCOS

Subject Area

Obstetrics and Gynecology

How to Cite This Article

Ria, Hanaa Fathi Abo; Mohammed, Hanan Abd El-Monem; and Hemida, Hoda Ismail Sayed (2023) "Effect of Metformin and Myo-inositol in Patients with Polycystic Ovary Syndrome," Al-Azhar International Medical Journal: Vol. 4: Iss. 11, Article 37.
DOI: https://doi.org/10.58675/2682-339X.2049