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Document Type

Original Article

Abstract

Background: Cesarean section is the biggest postpartum infection risk factor. Cesarean births increase the risk of infection and infectious morbidity. Post-c-section complications include fever, infection of the incision, endometritis, and urinary tract infection. Occasionally, pelvic abscess, bacteremia, septic shock, necrotizing fasciitis, and septic pelvic vein thrombophlebitis manifest. First-generation cephalosporins kill Gram-positive bacteria. Metronidazole injection treats severe bacterial infections. Aim and objectives: To compare between first-generation cephalosporin (cefazolin) versus combined first-generation cephalosporin and intravenous metronidazole in prevention of post-operative surgical site infection following cesarean section. Subjects and Methods: This was a double blinded compaative study that was carried out at the obstetrics and gynecology departments of Al Azhar University Hospitals, El Hussein, and Alexandria maternity hospital - Ministry of health. This Randomized prospective double blinded study included 300 pregnant women ± 38 weeks opting for an elective Caesarean Section. Patients divided into two groups, Group 1: 150 patients had been treated with first-generation cephalosporin and Group 2: 150 patients had been treated with combined first-generation cephalosporin I.V metronidazole. Results: The weight and gestational age ranges were not of significant difference between the cefazoline and cefazoline with metronidazole groups. However, there was a significant increase in hospital stays for the cefazoline group compared to the metronidazole group. The cefazoline-only group had significantly higher rates of endometritis, purulent wound discharge, and wound infection compared to the cefazoline-plus-metronidazole group. Conclusion: Cefazolin plus metronidazole is superior for C-section antibiotic prophylaxis, according to this study. Cefazolin plus metronidazole may minimize postoperative infection morbidity and hospital costs

Keywords

Cephalosporin; Metronidazole; Cesarean Section.

Subject Area

Obstetrics and Gynecology

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