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Document Type

Original Article

Abstract

Background: In affluent nations, polycystic ovarian syndrome is the leading cause of an ovulatory infertility, affecting between 5 and 10 percent of women of reproductive age. Due to its ease of use, cheap cost, relative safety, and success, clomiphene citrate has been the gold standard therapy for induction of ovulation in women with polycystic ovarian syndrome for many decades. Aim: to identify patient criteria for successful initiation of oogenesis by polycystic ovarian syndrome & clomiphene citrate. The Patients and the Techniques: in this study, we focused on obstetrics and Gynecology department, Faculty of Medicine, Al-Azhar University. The study included One hundred patients suffering PCOS after taking a written informed consent from every patient involved, they divided into two groups Successful (n=65) and Failed (n=35). Results: There was high major dissimilarities in the two groups' ages, weights, BMIs, and prevalence of thyroid illness. hormonal profile, follicular diameter and endometrial thickness and Correlations between Success and different parameters. There were insignificant difference among groups as regard Infertility type and duration, parity, TSH level (u IU/ml) and Prolactin (ng/ml). Conclusion: the current study showed that the risk factors for failed Clomiphene citrate stimulation of ovulation in polycystic ovarian syndrome included older age, higher BMI, higher weight, thyroid disease, free testosterone, DHEA, FSH, LH level, lower follicle diameter and endometrial thickness at day 14. patients’ Pcos patients who use clomiphene citrate to induce ovulation do not fare better if they meet certain requirements.

Keywords

Polycystic ovarian syndrome; ovulation; clomiphene citrate.

Subject Area

Obstetrics and Gynecology

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