Document Type
Original Article
Abstract
Background: One of the most frequently prescribed drugs for the treatment of seizures is phenytoin. The most frequently documented side effect of phenytoin is hepatotoxicity, and catastrophic outcomes following phenytoin-induced liver damage have been observed in 10 to 38% of patients. On the other hand, Liv 52 DS is an herbal supplement that have benefits for liver-induced hepatotoxicity.
Aim: to evaluate the histopathological restorative effects of varied doses of liv 52 ds when the liver hepatotoxicity is induced with phenytoin.
Subjects and methods: thirty adult albino rats had been divided into six groups, each with five animals. All groups received drugs orally for 45 days. Group 1 (control): received carboxymethyl cellulose. Group 2: received 20 mg/kg/day of phenytoin. Groups 3: received 20 mg/kg phenytoin plus 100 mg/kg/day liv 52 ds. Group 4: received 20 mg/kg phenytoin plus 200 mg/kg/day liv 52 ds. Group 5: received 20 mg/kg phenytoin plus 300 mg/kg/day liv 52 ds. Group 6: received 20 mg/kg phenytoin plus 500 mg/kg/day liv 52 ds.
Results: as regard treated groups, liver in group 2 showed slightly edematous portal tracts, inflammatory cells focally creeping on the limiting plate, cytoplasmic vacuolization, prominent cytoplasmic and perineuclear vacuolization in periportal hepatocyts and inflammatory cells at the limiting plate. Group 3 showed many inflammatory cells, mainly eosinophils. Group 4: showed prominent cytoplasmic vacuolization. Group 5: hepatocytes showed no vacuolization, portal tracts with ductular reaction as a sign of healing, no inflammatory cells and prominent bile duct proliferation. Group 6: showed near normal hepatocytes, with slightly resolved ductular reaction and no inflammation nor cytoplasmic vacuolization.
Conclusion: Liv.52 DS tablet administration showed marked beneficial improvement and enhanced hepatocellular repair and reduced hepatocellular damage when the liver hepatotoxicity is induced with phenytoin.
Keywords
Liv 52 DS, phenytoin hepatoxicity, Hepatoprotective.
Subject Area
Forensic Medicine.
How to Cite This Article
Mohamed, Ahmed Fathi; Moawad, Mohamed Ali; Yousef, Abdalrahman Mohammed; and Zain, Muhammad
(2023)
"Liv 52 DS Restorative Effects of Phenytoin Induced Hepatoxicity on Adult Albino Rats,"
Al-Azhar International Medical Journal: Vol. 4:
Iss.
11, Article 28.
DOI: https://doi.org/10.58675/2682-339X.2096
