Document Type
Original Article
Abstract
Background: Cadmium is a neurotoxin, especially to developing brains. Due to their still-developing nervous systems and blood-brain-barrier, very preterm newborns are particularly susceptible to the effects of neurotoxic substances. Aim: To determine the relation between pre-/post-transfusion erythrocyte cadmium levels in premature infants & its concentrations in the packed red blood cells donated by smokers and non-smokers blood donors. Patients and methods: A case control study included 30 premature infants from NICU. All of the donated blood were examined for HCV, HBs Ag, HIV, syphilis Auto Ab before use. Blood samples were collected before and six hours after blood transfusion from 15 premature infants transfused by smokers’ blood and 15 premature infants transfused by non-smokers blood. Results: The mean of cadmium percent changes before and after blood transfusion is significantly greater in group I than group II (480% vs 129 %) (p value = 0.000). There was a significant association amongst Gestational age, neonatal weight and volume transfused with cadmium level after transfusion (p value = (0.012, 0.002, 0.01). Conclusion: The PRBCs donated by smokers is a source of cadmium that are probably not safe for transfusion in premature infants.
Keywords
Cadmium, Premature Infants, Blood Transfusion
Subject Area
Clinical Pathology
How to Cite This Article
Ghanem, Duaa Ashraf; Ali, Wael Esmat; Hamed, Amira Mohammed Mohammed; and Abdelmeguid, Mona Mohamed
(2023)
"Cadmium Levels in Premature Infants Exposed to Blood Transfusion,"
Al-Azhar International Medical Journal: Vol. 4:
Iss.
11, Article 26.
DOI: https://doi.org/10.58675/2682-339X.2088
