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Document Type

Original Article

Abstract

Background: The invasiveness and possible morbidity of axillary lymph node dissection (ALND), the conventional strategy for assessing lymph node health for the past century, have brought into doubt the procedure in the last 15 years.

Aim of the work: The current study aims to assess the possibility of avoiding the morbidity of an ALND by staging an axilla using sentinel lymph node biopsy (SLNB) following neoadjuvant therapy (NAT) in previously diagnosed node-positive axillas in cancer of the breast.

Patients and methods: This prospective cohort research intends to involve a total of fifty participants. All of these women have breast cancer that has spread to their lymph nodes. These individuals will be recruited in a prospective cohort study that will performed from April 2021 to March 2023 at the Department of Surgery of the Al-Azhar University Hospitals in Cairo, Egypt.

Results: Patients in this research had an average age of 47.6 years and were all females with early-stage breast cancer with no history of other malignancies or lymphadenopathy.

Conclusion: When both radioactive colloid and blue dye are utilized to identify the SLN, the detection rate is higher, and FNR after NAC is better, allowing for the possible omission of axillary dissection following a positive sentinel lymph node(SLN). It has been debated whether or not depending on SLNB following NAC is acceptable for women who arrive with clinically positive nodes. When identifying SLNs in these individuals with two agents, FNRs are likewise reduced to the 10% range or below. The FNR is constantly below 10% when three or more SLNs are found, and this trend holds true regardless of the starting point.

Keywords

ALND; Chemotherapy; Breast cancer

Subject Area

General Surgery

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