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Document Type

Original Article

Abstract

Background: Antipsychotic drugs (APs) are the base for the pharmacological therapy of schizophrenia (SZ) and other psychotic disorders. Antipsychotics intoxication side effects are commonly including decrease level of consciousness, seizures and extra pyramidal symptoms. Objective: To shed light on the incidence of APs intoxication in Al-Azhar University Hospital (New Damietta) from the 1st of December 2020 to the end of November 2022. Patients and methods: It involved 146 cases who admitted to toxicology unit and after arrival to the hospital, 10 mL of blood was separated and the serum was used for detection of APs by using a high-performance liquid chromatography (HPLC) and other blood samples were stored at -8 ˚C for random blood sugar, hemoglobin levels, kidney function tests, arterial blood gases, creatine kinase, myoglobin blood levels and liver enzymes. Urine drugs screen and echocardiographic (ECG) changes were recorded then treatment to all cases were done. Results: Adult young, females, singles, students cases were the most frequently affected. The majority of cases were had a history of mental illness. Clozapine drug was the most commonly used. Suicidal manner was the most common. Decreased level of consciousness was the most common clinical presentation followed by extrapyramidal symptoms. Conclusions: No correlation between ingested APs doses and serum APs blood levels, neuroleptic malignant syndrome occurred with normal drug doses in old ages and recovery outcome was the most common result.

Keywords

Antipsychotic drugs; Intoxication; Detection; HPLC

Subject Area

Forensic Medicine.

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