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Abstract

Background: Chronic Kidney Disease postulated to be a constitutional pathology with interlacing between different etiological and pathogenic factors, which lead to ESRD. These pathogenic factorssuch as MCP-1, Neopterin and MCSF control migration of mediators that cause damage of renal tissue and play a role in the process inflammation.

Aim: confirming the presence of the sensitive markers for renal parenchymal damage, monocyte chemoattractant protein-1, neopterin, and macrophage colony-stimulating factor in patients' urine and serum as well as the progression of those patients to end-stage renal disease.

Methodology and Patients: This prospective case-control study, which included two equal groups of forty candidates each, was conducted at the hospitals affiliated with Al-Azhar University. Twenty patients receiving regular hemodialysis for chronic kidney disease with mean age of (9.60 ± 1.85), they were 10 males and 10 females (Group 1). Twenty apparently healthy children with mean age was (8.15 ± 2.76), they were 10 males and 10 females (group 2).

Results: With a p value of 0.001, there is a statistically significant variation between the studied groups in terms of serum levels of MCP-1 and neopterin.With a p value of 0.072, there is no statistically significant difference between the studied groups in terms of serum levels of MCSF.Regarding urinary levels of MCP-1, MCSF, and Neopterin, there is a statistically significant difference between the three groups with a p value 0.001.

Conclusion: MCP-1, Neopterin and MCSF can be future biomarkers for early detection of renal affection in patients with CKD and can be useful for prognosis of progression of CKD.

Article Type

Original Article

Keywords

CKD;Biomarkers; MCP-1; MCSF; Neopterin;Hemodialysis

Subject Area

Pediatrics & its Subspecialty.

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