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Document Type

Original Article

Abstract

Background: Preeclampsia develops in the placenta, beginning with insufficient cyto-trophoblastic invasion and concluding with extensive endothelial dysfunction in the mother. Elevated 1st trimester uterine artery mean resistivity index (RI) is significantly connected with fetal IUGR. Serum β-hCG levels in the 1st trimester can predict pregnancies that subsequently develop preeclampsia & associated fetal IUGR. Objective: to study the role of first trimester maternal uterine artery Doppler and serum Beta human chorionic gonadotropin (β-hCG) in prediction of preeclampsia and intra uterine growth restriction. Patients and methods: This study analyzed data from pregnant women who went to the obstetric out-patient clinic at Al-Azhar University in Cairo, Egypt, as part of their regular prenatal treatment at 11-14 weeks of gestation they were subdivided into a case group (A) & a control group (B). The case group consists of 80 females. Results: a statistically significant distinction existed among the 2 groups regarding to BHCG level, Mean RT uterine artery RI&PI, Mean LT uterine artery RI&PI, Presence of diastolic notch in uterine artery, Gestational age and Development of preeclampsia. There was no statistically significant variance amoung the 2 groups regarding to Maternal age . Conclusion: Abnormal uterine artery Doppler studies  in the first and second trimesters have been linked to adverse pregnancy outcomes such as pre-eclampsia, fetal growth restriction and perinatal mortality. On the other hand, Doppler testing appears to have a limited predictive value in women at low risk, and there are no measures available to avoid unfavorable outcomes based on aberrant results.

Keywords

Doppler; Preeclampsia; IUGR-BHCG.

Subject Area

Obstetrics and Gynecology

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