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Corresponding Author

Mohamed, Mohamed

Document Type

Original Article

Abstract

Introduction: Preterm labor (before 37 weeks of gestation) is a major cause of death, as well as a substantial cause of death and long-term loss of human potential. To prevent premature delivery, both nifedipine and progesterone can be administered as tocolysis. Objective: To examine the efficacy and safety of nifedipine and progesterone for maintaining tocolysis following preterm labour arrest, as well as their perinatal outcomes. Patients and methods: Our study included 60 women with a history of preterm labour to compare the efficacy and safety of nifedipine and progesterone for tocolysis maintenance and preterm labour prevention. Results: A high statistically significant higher gestational age, less preterm birth, decrease NICU admission and duration, with less complications as hypotension, headache, and tachycardia with p-value <0.001, <0.001, 0.026, 0.008. Conclusion: Progesterone exhibited a superior tocolytic effect than nifedipine for preventing premature labour, with more pregnancy duration and less NICU admission with shorter NICU stay, higher gestational age, and fewer adverse symptoms such as hypotension, headache, and tachycardia.

Keywords

preterm birth; Tocolysis; Nifedipine; progesterone

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