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Corresponding Author

Ghoniem, Islam

Document Type

Original Article

Abstract

Background: M2-pyruvate kinase (M2-PK) plays an important role in tumor metabolism, and new studies have shown that M2-PK can operate as both a protein kinase and a transcription factor coactivator. It could dynamically regulate glycolysis energy generation and synthesis processes and is a key regulator of tumor growth. The aim of the work: to evaluate the diagnostic relevance of plasma M2-pyruvate kinase in Egyptian colorectal cancer patients. Patients and Methods: The research has been performed on eighty (80) people who fulfilled the designed inclusion criteria. The study was conducted at the outpatient clinic of the Gastroenterology department as well as at the inpatient unit of the Gastroenterology department of Internal Medicine departments, at El-Galaa Family Military Hospital and Al-Houssein University Hospital. Results: There had been a statistically significant difference in M2 pyruvate kinase levels between the control and patient groups. The M2 pyruvate kinase level was significantly greater in colorectal cancer then colorectal polyp then IBD. In conclusion: Plasma M2-Pyruvate Kinase (M2-PK) levels have been significantly higher in patients with colorectal cancer (CRC) than in healthy subjects or other patients with colonic lesions and may be useful in distinguishing CRC patients from those with benign colonic lesions.

Keywords

IBD; colorectal polyp; colorectal cancer; M2 pyruvate kinase

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