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Corresponding Author

Hussein, Ibrahem

Document Type

Original Article

Abstract

Background: Unopposed oestrogen is thought to play a key part in the progress of endometrial benign, premalignant, and malignant lesions, according to various epidemiologic and experimental investigations. Objective: To compare the special effects of metformin and progesterone on disorganised proliferative endometrium and simple endometrial hyperplasia and determine whether metformin is clinically effective in this circumstance. Patients and Methods: This was a double blinded randomized controlled trial, was carried out on 100 patients at The Department of Obstetrics & gynecology at Al-Hussein University Hospital and El-Mahalla General Hospital, divided into 2 groups: (group1); 50 cases treated with metformin (Glucophage) 500 mg in the 1st week to 100 0 mg in the 4th week, (group2); 50 cases was managed medroxyprogesterone acetate (provera) 400mg daily for three months. Result: There was no statistically significant difference between the two studied groups regarding uterine bleeding after treatment (p= 0.47), endometrial thickness after treatment (p= 0.706). Also, there was no statistically significant difference between the two studied groups as regards patient’s satisfaction and hysterectomy. The duration of treatment didn’t differ significantly between the two groups. There was high statistically increase in incidence of painful breast, weakness and metallic taste in group 1 compared to group 2 while there was high statistically increase in incidence of nausea, vomiting and diarrhea in group 2 compared to group 1. Conclusion: Metformin could be effective as well as progesterone in resolving of benign endometrial proliferative lesions. Endometrial proliferative lesions should be detected with good management to avoid its complications.

Keywords

Metformin; progesterone; Endometrium; perimenopausal bleeding

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