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Corresponding Author

al sagheer, alaa eldeen

Document Type

Original Article

Abstract

ABSTRACT Background Clomiphene Citrate (CC), a selective estrogen-receptor modulator is used to manage polycystic ovary syndrome, but it has harmful implications Aim and objectives: To identify the histological results of CC on the kidneys of female albino rats and the protective effects of ascorbic acid Material and methods: Forty-eight adult female albino rats were selected for this 21-days experiment. They were randomly divided into equal four groups. Group (I): control group, Group (II): given Ascorbic acid (25mg per Kg. BW) daily for 21 days, Group (III): given orally Clomiphene Citrate (1.2 mg per Kg. BW) daily for 21days, Group (IV): CC plus Ascorbic acid. Retroocular Blood samples for renal function tests Specimens from the kidneys of every rat were taken for histological examination by the LM & EM Results: Degenerative changes in the kidneys of group III, in the form of vacuolation in the cells of the proximal and distal convoluted tubules (PCT&DCT), Disappearance of the brush border of the (PCT), Congestion of glomerular capillary tufts and change of the Bowman’s space. The podocyte's pedicle appeared degenerated. In group IV, vacuolation in (PCT&DCT) was mild. The proximal tubules appeared normal and their cells' brush borders were restored. The glomerular capillary tufts were similar as in group I, with good cellularity and Bowman’s space. The podocyte's pedicle appeared to be almost intact Conclusion: CC has harmful effects on the components of the kidney. Ascorbic acid has a protective effect against the harmful effects of CC as restoring the normal appearance

Keywords

Clomiphene citrate; ascorbic acid; kidney

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