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Corresponding Author

Abdel-Hady, Mohamed

Document Type

Original Article

Abstract

Background: The effectiveness of identifying individuals with pre-diabetes to prevent type 2 diabetes has been intensely debated. Clinical trials demonstrating that lifestyle modification and drug-based interventions could prevent or delay progression to type 2diabetes provide some robust evidence. Aim of the work: The aim of this work was to study and early discover early complications either microvascular or macrovascular in both patients of prediabetes and medical syndrome. Patients and methods: This study was a prospective case control study carried out at Al-hussein university hospital. This study included 30 patients with prediabetes (group A), 50 patients with type 2 DM (group B), and 50 healthy controls (group c). Diabetics and prediabetics had significantly higher mean of age and BMI than control group. Results: There is a significant difference between the two groups (prediabetes and diabetes) regarding retinopathy, neuropathy, nephropathy, hyperlipidemia and hypertension. Conclusion: Both diabetes and prediabetes predispose patients to the development of complications of diabetes, through complex molecular pathways that involve hyperglycemia and insulin resistance. While intensive glycemic control alone might not reduce mortality and major events, a global approach consisting of life-style modifications, decreasing hyperglycemia, and treating cardiovascular risk factors associated with diabetes is beneficial to the cardiovascular risk profile of those patients; hence, the target of blood glucose control should be tailored to the individual patients.

Keywords

Prediabetes; microvascular; macrovascular; Type 2 Diabetes; Insulin Resistance

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