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Corresponding Author

Reihan, Mohamed

Document Type

Original Article

Abstract

Abstract Background: Keloids are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems. Intralesional injection treatments show promising results and many agents have been used as single treatments or in combination to get the best result. Patients and Methods: This is a prospective comparative non-randomized clinical study including 20 patients with 30 keloid lesions divided into 3 groups A, B and C including 10 lesions each. Group A received intralesional injection of Botulinum toxin Type A (BTX-A) 2 U/cm2, Group B was treated with Methotrexate (MTX) 1 mg/cm2 and group C with Verapamil 0.125 mg/cm2. Results: The percentage of improvement of VSS was better in group A than group C which was statistically significant (p2=0.01). Also, group B was better than group C in the percentage of improvement of VSS which was statistically significant (p3<0.01), while, there was no statistically significant difference in the percentage of improvement between group A and group B (p1=0.233). Conclusion: our study supports the efficacy of the 3 mentioned drugs in treatment of keloids with better results obtained from intralesional injection of Botulinum Toxin A and Methotrexate than Verapamil.

Keywords

Keloid; Botulinum toxin; Methotrexate; Verapamil

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