Evaluation of Intralesional Injection of Platelet Rich Plasma Compared with Mitomycin-C plus Dexamesathone in Treatment of Peyronie’s Disease

Authors

Ahmed Farrag, Dermatology faculty of medicine Suez universityFollow
ahmad Awwad, Professor of Andrology, Venerology and Sexology, Faculty of Medicine, Cairo University, EgyptFollow
Abdel Raouf AL Mohsen, Professor of Dermatology, Venerology and Andrology, Faculty of Medicine, Al-Azhar University, EgyptFollow
Sameh Fahmy, Assistant Professor of Dermatology, Venerology and Andrology, Faculty of Medicine, Al-Azhar University, EgyptFollow
Magdy Hassan, Lecturer Professor of Dermatology, Venerology and Andrology, Faculty of Medicine, Suez University, EgyptFollow

Corresponding Author

Farrag, Ahmed

Document Type

Original Article

Abstract

Background: Peyronies disease (PD) is a physically and psychologically debilitating illness marked by a fibrous inelastic tunica albugenia scar that results in a visible penile scar and deformity. Objective: In order to assess the efficacy of intralesional injection of platelet rich plasma to Mitomycin-C with Dexamesathone in the treatment of Peyronie's Disease, researchers conducted a study. Patients and methods: This study was Prospective interventional randomized comparative trial carried out on adult's male Patients with Peyronie's disease who visited the Andrology outpatient clinic, Kasr El Aini Hospital, and Cairo University. Only 50 patients with Peyronie's disease were included in the first screening of 75 patients who complained of PD. The study enrolled those who met the inclusion criteria. Results: There was a statistically significant improvement in PDQ domains, and IIEF scores after treatment with no superiority of neither option. Additionnaly, degree of curvature and erectile dysfunction improved in both groups after treatment as well; but to a different extent. Conclusion: Intralesional injection of PRP and Mitomycin-C plus Dexamesathone could improve Peyronie’s Disease symptoms. Mitomycin-C plus Dexamesathone more effective than PRP Penile curvature and plaque size improvement, while PRP was more effective in improvement of erectile function.

Keywords

Peyronie’s disease; platelet rich plasma; mitomycin-C

How to Cite This Article

Farrag, Ahmed; Awwad, ahmad; AL Mohsen, Abdel Raouf; Fahmy, Sameh; and Hassan, Magdy (2022) "Evaluation of Intralesional Injection of Platelet Rich Plasma Compared with Mitomycin-C plus Dexamesathone in Treatment of Peyronie’s Disease," Al-Azhar International Medical Journal: Vol. 3: Iss. 3, Article 14.
DOI: https://doi.org/10.21608/aimj.2022.105779.1674