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Corresponding Author

elsafty, mohamed

Document Type

Original Article

Abstract

Abstract Background: Testosterone deficiency is common in chronic kidney disease patients, clinical studies reported that about 50–70% of men on dialysis are affected by hypogonadism. Objective: Changes in sex hormones (free testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin) in male patients with chronic kidney disease (CKD), end-stage renal disease (ESRD) on regular hemodialysis, and post-renal transplantation patients were investigated. Patients and methods: This was a prospective comparative study conducted on 90 patients (30 male CKD patients stage 4, 30 male ESRD patients on regular hemodialysis and 30 male patients with post renal transplantation), at Maadi Military Medical Complex during the period from January 2020 to July 2021. Results: In post-renal transplantation group-3, there was a highly significant rise in baseline free and total Testosterone, LH, and FSH when compared to the other groups (p 0.01 correspondingly). In post-renal transplantation group-3, there was asignificant drop in baseline Estradiol and Prolactin associated to the other groups (p 0.01 correspondingly). In post-renal transplantation group-3, there was a highly significant rise in follow-up (12-month) free and total Testosterone, LH, and FSH when compared to the other groups (p 0.01 correspondingly). In the post-renal transplantation group-3, there was a highly significant drop in Estradiol and Prolactin at the 12-month follow-up linked to the other groups (p 0.01 correspondingly). Conclusion: Kidney transplantation has been connected to improve erectile function in ESRD patients. This is directed by a rise in serum testosterone and a decrease in luteinizing hormone and prolactin levels.

Keywords

Renal transplantation; Gonadal Hormones; End Stage Renal Disease; Chronic Kidney Disease

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