Zinc and Abdominal Aortic Calcification in Patients under Regular Hemodialysis

Authors

Omar Sayed, internal medicine faculty of medicine Al -azhar university cairo egyptFollow
Safwat Ahmed, Internal Medicine and Nephrology department, Faculty of Medicine, Al-Azhar University, EgyptFollow
Hani Ismail, Internal Medicine and Nephrology department, Faculty of Medicine, Al-Azhar University, EgyptFollow
mohamed elfeshawy, Diagnostic Radiology department, Faculty of Medicine, Al-Azhar University, EgyptFollow
Mohamed Ibrahim, Clinical Pathology department, Faculty of Medicine, Al-Azhar University, EgyptFollow

Corresponding Author

Sayed, Omar

Document Type

Original Article

Abstract

Background: Vascular calcification is known to be significantly influenced by zinc deficiency. Low serum zinc inhibited the osteochondrogenic phenotypic flip of phosphate-induced vasculature smooth muscle cells (VSMCs), which led to the formation of vascular calcification. Abnormal mineral metabolism, like hyperphosphatemia, which leads to the phenotypic conversion of VSMCs into osteoblasts that secrete collagen, is a contributing factor for the development of arterial calcification in CKD. Aim and objectives: The goal of this research was to evaluate the link between zinc and abdominal aortic calcification in individuals receiving regular hemodialysis. Subjects and methods: This Cross-Sectional research included 40 Hemodialysis Patients The study Will Be Conducted In Nephrology Unit Al Hussien Hospital. All patients receive 3 Hemodialysis sessions weekly. Results: AAC score and age have a strong positive link (r = 0.56) that is statistically substantial (p-value< 0.001). AAC score and BMI have a statistically substantial (p-value = 0.014) negative connection (r = -0.39). AAC score and albumin have a strong negative connection (r = -0.55) that is statistically substantial (p-value < 0.001). AAC score and PTH have a statistically substantial (p-value = 0.036) positive connection (r = 0.33). AAC score and serum zinc have a statistically substantial (p-value = 0.005) negative connection (r = - 0.43). Conclusion: Low serum zinc is connected with high odds of having AAC.

Keywords

zinc; Abdominal Aortic Calcification; Hemodialysis

How to Cite This Article

Sayed, Omar; Ahmed, Safwat; Ismail, Hani; elfeshawy, mohamed; and Ibrahim, Mohamed (2022) "Zinc and Abdominal Aortic Calcification in Patients under Regular Hemodialysis," Al-Azhar International Medical Journal: Vol. 3: Iss. 12, Article 33.
DOI: https://doi.org/10.21608/aimj.2023.149854.2039