Electron Microscopic and Histopathological Study of the Overacting Inferior Oblique Muscle of the Human Eye

Authors

Mohamed Kandeel, Anatomy and Embryology Department, Faculty of Medicine, Al-Azhar University, Cairo, EgyptFollow
Gamal Desouki, Anatomy and Embryology Department, Faculty of Medicine, Al-Azhar University, Cairo, EgyptFollow
Alaa El Deen El Sagheer, Anatomy and Embryology Department, Faculty of Medicine, Al-Azhar University, Cairo, EgyptFollow
Amr ELkamshoshy, Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptFollow

Corresponding Author

Kandeel, Mohamed

Document Type

Original Article

Abstract

ABSTRACTBackground: Inferior oblique muscle overaction is a common disorder that has a correlation with the anatomical changes of the muscle itself. The changes differ according to the grade of the overaction.Objective: To correlate between the histopathological alternations of the inferior oblique muscle and the different degrees of clinical overaction.Patients and methods: Ten biopsies from inferior oblique muscles were taken during the surgery of strabismus after determining the clinical degree of the overaction. One muscle biopsy was taken during enucleation surgery and considered as a control. All biopsies were examined by light and transmission electron microscopes.Results: By light microscopy, grade II and grade III inferior oblique overaction showed many histopathological findings as muscle fibers degeneration, variable size of muscle fibers, nerve bundles hypertrophy and fibro-fatty infiltrations. Grade III inferior oblique overaction showed fibrosis of perimysium and endomysium, mononuclear infiltration and fatty infiltration. By transmission electron microscopy the muscle fibers showed increased mitochondrial number and mitochondrial variability in shape and size, also showed increased vacuoles and fat droplets.Conclusion: Histopathological alternations in the inferior oblique muscle correlate to the clinical grades of the muscle overaction.

Keywords

Inferior oblique; overaction; Histopathological; Electron Microscope

How to Cite This Article

Kandeel, Mohamed; Desouki, Gamal; El Sagheer, Alaa El Deen; and ELkamshoshy, Amr (2021) "Electron Microscopic and Histopathological Study of the Overacting Inferior Oblique Muscle of the Human Eye," Al-Azhar International Medical Journal: Vol. 2: Iss. 7, Article 1.
DOI: https://doi.org/10.21608/aimj.2021.76587.1477