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Corresponding Author

El Wakeel, Hassan

Document Type

Original Article

Abstract

Background: Monosodium Glutamate (MSG) is one of the most widely used food-additives in commercial foods. The excessive MSG administration may lead to damage of many organs including the testes. Ginger is medicinal plant, medically used for its antioxidant protection activity and it has a beneficial effect on male reproductive functions. Aim of the study: This study was performed to find out the effect of MSG on the histology of the seminiferous tubules of adult albino rats and possibility of recovery without treatment and administration of ginger. Material and methods: sixty adult male albino rats were divided into three equal main groups, each of which included 20 rats. Control group (C) kept without treatment, treated group (T) which divided into two subgroups (T1): which were given monosodium glutamate daily orally for 14 days. (T2): which were given monosodium glutamate daily orally and ginger daily orally for 14 days. Recovery group (R) which divided into two subgroups, (R1): which subdivided into two subgroups:(R1a) & (R1b): which were given monosodium glutamate daily for 14 days followed by 6and 13 days without treatment sequentially. (R2): subdivided into two subgroups:(R2a) & (R2b): which were given monosodium glutamate daily and ginger for 14 days followed by continuous treatment with ginger only for 6 and 13days sequentially. Results: MSG causing alteration in the histological of testicular tissues. The testicular damage caused by MSG is reversible without treatment or with administration of Ginger. Conclusion: Ginger has protective effects against MSG on the rat testicular tissue.

Keywords

mono sodium glutamate; Ginger; albino rats; testes

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