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Corresponding Author

Mohamed, Shady

Document Type

Original Article

Abstract

Background: The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1.73 m², or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Objective: This study was planned to investigate the association between the inflammatory biomarkers including [C reactive protein (CRP) and tumor necrosis factor alpha (TNFα)] and end stage renal disease (ESRD). Patients and Methods: 60 subjects were enrolled in this study. They were divided into 30 control and 30 patients on hemodialysis. Serum TNFα and CRP of ESRD patients early diagnosed and 6 months after dialysis were measured compared to the control. Results: There was highly statistical significant difference between control and ESRD patients in TNFα and CRP early diagnosis and 6 months after dialysis. Regarding difference between early diagnosis and also 6 months after dialysis in ESRD group there was statistical significant difference in both. There was also no statistical significant difference linear relationship between serum CRP level early diagnosed and 6 months after dialysis with other studied parameters in patients groups. Conclusion: TNFα and CRP has increased in ESRD patients early diagnosed and markedly increased 6 months after dialysis compared to control. TNFα and CRP were both associated with the prevalence of ESRD. There was statistically significant linear relationship between serum TNFα level early diagnosed and the age in patients groups.

Keywords

End Stage Renal Disease; Tumor necrosis factor α; C reactive protein

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