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Corresponding Author

Mohamed, Rabea

Document Type

Original Article

Abstract

ABSTRACT OBJECTIVES: To study the effects of the first single dose of tamsulosin 0.4 mg on lower urinary symptoms tract (LUTS) in patients with benign prostatic hyperplasia (BPH) as an indication of the response at 3 months after treatment. PATIENTS AND METHODS: This was a prospective study that included patients> 45 years old with LUTS / BPH. In all patients, tamsulosin was administered orally 0.4 mg once a day for 3 months. The degree of international prostate symptoms (IPSS), quality of life (QoL), residual urine volume (PVR) and maximum urine flow rate (Q max) were measured before treatment, 6 hours, 10 days, 1 month and 3 months after treatment. Data before and after treatment were compared using appropriate statistical analysis tests. Results: The group included 60 patients. They ranged in age from 45 to 70 years (56.38 ±7.25 years). No significant differences were observed between baseline data and the sixth hour after treatment. IPSS, QoL points, PVR and Qol data of 49 (81.7%) of the patients have improved significantly from the tenth day to the end of study after 3 months (p <0.05). Eleven patients (%18.3) did not respond to the tamsulosin and another treatment options for their LUTS/BPH had been offered. Conclusion: Tamsulosin hydrochloride has achieved a significant improvement of patients with LUTS/BPH in terms of IPSS, QoL points, PVR and Qol 10 days after treatment. There is no relationship between the tamsulosin effect achieved after the initial dose and its mid-term effectiveness.

Keywords

First Dose; Tamsulosin; Predictive ability; Benign Prostatic Hyperplasia

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