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Corresponding Author

Raafat, el Sayed

Document Type

Original Article

Abstract

Background: Breast cancer is the most frequently diagnosed cancer globally and is the leading cause of cancer-related death in women. The American Cancer Society estimates that 249, 260 Americans will be diagnosed with invasive breast cancer. Objectives: This is a retrospective study aiming to identify the frequency of amenorrhea (ovarian failure) after different chemotherapy regimens in premenopausal patients with breast cancer as well as the associated other risk factors that could influence the rate of amenorrhea. Patients and Methods: This study will include patients with breast cancer with at least a minimum follow up of six months after last cycle of chemotherapy either clinically or by E2 and FSH. Expected number of enrolled patients in this study is around 100 patients. Results: Patients who had HER 2 negative IHC stain had significantly lower rates of Chemotherapy Induced Amenorrhea (CIA) when compared to those HER 2 positives with p value 0.001. In our study we have found a correlation between DFS and CIA which imply that patients who had CIA had better survival than those with CIA however this difference was not significant, p value 0.129, Overall survival show no difference based on CIA p value 0.319. Conclusion: CIA is a main concern for females treated with breast cancer, it was found correlated to age, tumor stage, tumor biology and type of surgery. More prospective studies are needed to confirm correlation between CIA and prognosis of breast cancer, nonetheless other treatment regimens and malignancies should be investigated.

Keywords

Chemotherapy; Amenorrhea; Premenopausal Breast Cancer Patients

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