•  
  •  
 

Document Type

Original Article

Abstract

Background and Aim: Metabolic diseases, such as chronic low-grade inflammation, insulin resistance and adipocyte hypertrophy have been linked to obesity. The influence of perioperative probiotic administration on bariatric surgery yielded conflicting results. We directed this randomized controlled study to outline the effects of probiotic administration on the effects of laparoscopic sleeve gastrectomy. Patients and Methods: This randomized, double-blinded, placebo-controlled study included 83 cases, undergoing laparoscopic sleeve gastrectomy, to take either probiotics or placebo. The primary result was the anthropometric measurement at 3 months after the surgery. The secondary outcomes included lipid profile, glycemic control and serum vitamins D and B12. Results: The anthropometric measurements showed non-significant comparison between probiotics and placebo, three months after laparoscopic sleeve gastrectomy. Probiotics was associated with better glycemic control, reduced triglyceride and cholesterol levels and higher values of serum vitamin D and B12. No significant difference was reported among the two groups, regarding the rate of complications. Conclusion: Our findings suggested that probiotic supplementation had little effects on the anthropometric measures in the early postoperative period after bariatric surgery. Probiotic administration improved the lipid profile by lowering triglyceride and cholesterol levels. This randomized controlled trial demonstrated a substantial increase in vitamins B12 and D levels in the probiotics group. Finally, further increased quality trials are required in demonstrating the dose- and strain-dependent effects of probiotics administration after bariatric surgery.

Keywords

probiotics, Anthropometric indices, metabolic outcomes, laparoscopic sleeve gastrectomy.

Subject Area

General Surgery

Download

Share

COinS