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Document Type

Original Article

Abstract

Background: COVID-19 clinical manifestations are diverse, ranging from asymptomatic and moderate symptoms to severe diseases. It is difficult to anticipate the clinical course or identify people at risk of worsening.

Aim of the Work: To estimate prevalence of morbidity and mortality in COVID-19 infected patient and to evaluate risk factors associated with severity of COVID-19 infection.

Patients and Methods: 200 patients with COVID-19, one hundred patients had comorbid disease (cardiac, renal or hepatic) and 100 age and sex matching patients had no comorbid disease. Detailed history, clinical examination, radiological investigations and evaluation of illness severity were recorded for all patients.

Results: Non-survivors had significant increase in hypertension (HTN), chronic obstructive pulmonary disease, chronic kidney disease (CKD) and stroke when in comparison to survivors. Dead cases had significant increase in respiratory, cardiovascular, neurological, renal, hematological, endocrinal and dermatological complications when in comparison to alive cases. Dead cases had significant increase in ICU admission, higher incidence of need for more advanced modes of mechanical ventilation (MV), higher incidence of severe and critical hypoxia and higher incidence of need for MV.

Conclusion: COVID-19 infected patients with old age, associated comorbidities, specific laboratory and imaging criteria was found to be associated with death. Moreover, higher incidences of respiratory, cardiovascular, neurological, renal, hematological, endocrinal and dermatological complications as well as severe and critical hypoxia and ICU admission and MV were associated with death among Covid-19 patients.

Keywords

Clinical Outcomes; COVID-19; Morbidity; Mortality

Subject Area

Chest

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