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Document Type

Original Article

Abstract

Background: The noninvasive technique known as myocardial perfusion imaging is used to assess the functional relevance of borderline coronary artery abnormalities. Additionally, well-validated intrusive technique known as instantaneous wave-free ratio is employed for same objective, Aim and objectives; to compare perfusion imaging SPECT as a one of the commonly used noninvasive test in assessment of myocardial ischemia &instantaneous wave free ratio as one of the new invasive tools in evaluation of significance of moderate coronary artery disease lesion, Subjects & techniques; This is prospective research, conducted on 50 studied cases who were diagnosed as ischemic heart disease and admitted to National Heart Institute and Al-Azhar University hospitals. Those patients were subjected to coronary angiography that showed moderate lesion (angiographically) in a single vessel then patients who have IFR result between 0.8-0.9 were scheduled to MPI (SPECT) to assess the significance of this border line lesion within 2 weeks of coronary angiography, Result; There were 22 (44%) with positive IFR and the mean value of IFR was 0.88 (±0.08 SD) with range (0.75-1.04), Conclusion; both MPI SPECT&IFR found great sensitivity (90.9%), specificity(96.4%), NPV(93.1%), &PPV(95.2). So, instantaneous wave-free ratio can be valid alternative to fractional flow reserve to evaluate functional significance of intermediate coronary lesions without using agents to induce maximal hyperemia.

Keywords

Instantaneous wave-free ratio, myocardial perfusion imaging, and coronary artery lesion.

Subject Area

Cardiology

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