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Document Type

Original Article

Abstract

Background: The most frequent malignancy in women is breast cancer. Depending on the tumor's morphological traits, clinical characteristics, and hormone receptor levels, treatment outcomes can vary. In modern medicine, the levels of the progesterone receptor (PGR), oestrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) have been found to be important prognostic markers.

Aim of the work: To evaluate the clinicopathological features among the patients with early-stage triple negative breast cancer regarding progression free survival and overall survival.

Patient and methods: The Clinical Oncology and Nuclear Medicine Department at AL-Hussein University Hospital conducted this retrospective analysis between the beginning of January 2011 and December 2018. The records of sixty (60) patients who met the qualifying requirements were gathered, and clinicopathological information was taken from the patient files. Disease-free survival (DFS) was the primary goal, and overall survival was the secondary endpoint (OS).

Results: The results of the current investigation demonstrated a substantial correlation between bigger breast cancers and poor overall survival. Poor disease-free survival was significantly correlated with lymphovascular invasion.

Conclusion: Breast tumours that are triple-negative have poor prognoses. They are at a greater risk of invasion and have high histological grades. Early metastases can occur in this population, and the predicted survival is typically brief.

Keywords

Breast Cancer, Triple Negative Breast Cancer (TNBC), KI-67.

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