Role of Endosialin/CD248 and Cytoglobin In liver fibrosis

Authors

Mahmoud Abdallah Mansour, Lecturer of Internal Medicine Faculty of Medicine, Al-Azhar university ,assuit, egypt"Follow
Khaled Abd elazeme Eid, Professor and head of gastroenterology and hepatology department Faculty of Medicine, AL-Azhar university, assuit, egypt"Follow
Ashraf mohamed Elkabeer, Associate Professor of Internal Medicine Faculty of Medicine, AL-Azhar university, Assiut,Egypt"Follow
Eglal mohamed kenawy, Associate Professor of Internal Medicine Faculty of Medicine, AL-Azhar university , Assiut,Egypt"Follow
Bakheet elkot mostafa Elsadek, Associate Professor of Biochemistry Faculty of pharmacy, AL-Azhar university, Assiut,Egypt"Follow

Corresponding Author

Mahmoud Abdallah Mansour lecture of internal medicin al azhar university faculty of medicine azhar assiut hospital assiut , egypt. EMAIL. mansour1232003@yahoo.com

Document Type

Original Article

Abstract

Background - Chronic liver diseases are a major global health burden. CYGB, Human IV globin is abundantly expressed in Hepatic Stellate Cell(HSCs) between hepatocytes. CYGB can bind oxygen and nitric oxide and is said to protect HSCs from reactive oxygen species(ROS).

Aim - to estimate role of CD248 and Cygb in process of liver fibrosis.

Patients and Methods - This study was conducted on forty-four Egyptian patients with hepatic stenosis detected by ultrasound, and forty healthy volunteers as control group.

Results - Our results showed statistical significant (p-value < 0.001) increased CD248 in patients group (189.03 ± 66.6) when compared with control group (138.7 ± 36.5), decreased Cygb in patients group (1.62 ± 0.35) when compared with control group (1.93 ± 0.26)

Conclusion - Our study identified Cygb and CD248 as a novel therapeutic-targets in liver-fibrosis.

Keywords

CYGB, Chronic Liver Disease, fibrosis, CD248 .

Subject Area

Internal Medicine

How to Cite This Article

Mansour, Mahmoud Abdallah; Eid, Khaled Abd elazeme; Elkabeer, Ashraf mohamed; kenawy, Eglal mohamed; and Elsadek, Bakheet elkot mostafa (2023) "Role of Endosialin/CD248 and Cytoglobin In liver fibrosis," Al-Azhar International Medical Journal: Vol. 4: Iss. 8, Article 35.
DOI: https://doi.org/10.58675/2682-339X.1947