Document Type
Original Article
Abstract
Background: Measurement of RA disease activity helps guide therapeutic decision and follow up. Several disease activity scores (DAS) have been developed. DAS28 is the most frequently utilized score and the backbone for the European League Against Rheumatism (EULAR) response criteria.
Objective: To evaluate the possible association between ESR/CRP ratio, MPV, and PDW and rheumatoid disease activity.
Subjects and methods: Ninety individuals were included and subdivided into three age and gender matched groups: Group A: 30 RA patients who received conventional DMARDS, Group B: 30 RA patients who received biological DMARDS, Group C: 30 healthy volunteers as a controls. Each participant was subjected to history taking, musculoskeletal examination, disease activity score by DAS 28, laboratory tests including complete blood count (CBC), mean platelet volume(MPV), platelet distribution width(PDW), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).
Results: DAS28-CRP was more significantly reduced in biological DMARDs group than in conventional group at 6 months from baseline (p
Conclusion: MPV and PDW were significantly higher among RA patients than control individuals. Moreover, they have a significant association with disease activity in RA patients.
Subject Area
Biochemistry, Clinical Pathology, Pathology, Rheumatology and Medical Rehabilitation
How to Cite This Article
Ibrahim, Omar Ashraf Mohamed; Ghit, Mohamed Magdy; Assem, Ahmed Ali; and Hamoud, Hesham Salah
(2023)
"The Relationship between ESR/CRP Ratio, Platelet Indices and Rheumatoid Disease Activity,"
Al-Azhar International Medical Journal: Vol. 4:
Iss.
7, Article 28.
DOI: https://doi.org/10.58675/2682-339X.1897
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