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Document Type

Meta Analysis

Abstract

Background: Gynecomastia is a broadening of the glandular breast tissue and overlying skin in boys. The infection handle is related with uneasiness, trouble, decreased quality of life, and an unsuitable body picture

The aim of the study: To a meta-analysis Study of gynecomastia in children, through a process of combining the results of individual studies with statistical methods in one review, regarding the etiology, and management.

Patients and methods:this study was conducted in accordance with the Preferred Reporting Items for Meta-Analyses (PRISMA) statement (Moher et al., 2009).

Results: The starting look of distinctive databases, said some time recently, had recognized 521 reports from which 84 reports have been prohibited by EndNote program as copies. The titles and abstracts of the remaining 437 reports were screened, and revealed exclusion of 355 reports for not meeting the inclusion criteria. The complete writings of the remaining 82 reports, from the title and unique screening, were screened for qualification criteria. After prohibition of 58 reports, 24 papers of different study designs were eventually included for systematic review.

Conclusion:This systematic review and meta-analysis investigated the different etiological, clinical and therapeutic aspects of pediatric and peripupertal gynecomastia. Pediatric gynecomastia was significantly more associated with higher BMI and E2/T ratio. Imbalance between estradiol to testosterone levels and the increased sensitivity of estradiol are the main pathological mechanisms. Several techniques have been proposed in the literature to address gynecomastia. The combined use of surgical excision and aspiration techniques seems to reduce the rate of complications compared to surgical excision alone

Keywords

gynecomastia, estradiol, testosterone, aspiration, excision

Subject Area

Pediatrics & its Subspecialty.

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