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Document Type

Original Article

Abstract

Background: Systemic lupus erythematosus, sometimes known as SLE, is an autoimmune illness can have far-reaching effects on bodily functions. Renal impairment is among SLE's most devastating effects. It affects forty to seventy percent of patients. One of the most important chemokines in attracting monocytes and macrophages to areas of inflammation is monocyte chemoattractant protein-1 (MCP1). Aim and objectives: to determine if MCP-1 can aid in the early detection of lupus nephritis as well as look at any possible links among MCP-1 levels & disease severity in addition kidney function. Subjects and methods: 60 patients with age ranging between 20-60 years were chosen from internal medicine department at both Al Hussein and Sayed Jalal University Hospitals and outpatient clinic, with appropriate consent to participate in this trial. Result: There was a significant variance between the 3 examined groups related to Renal and LN parameters and Urinary MCP-1 levels. There was no significant change amongst the three researched groups regarding age, sex, BMI & disease duration. There was a considerable positive and strong correlation amongst the MCP-1 with urea, ESR, proteinuria, anti-dsDNA and renal SLEDAI. Conclusion: Our findings show that urine monocyte chemoattractant protein-1 (uMCP-1) levels are much higher and correlate well with LN activity in persons with active Lupus nephritis, especially those experiencing a renal relapse. Active LN and/or recurrence might be distinguished from inactive renal disease by using urine monocyte chemoattractant protein-1.

Keywords

Lupus nephritis (LN); systemic lupus erythematosus (SLE); Monocyte chemoattractant protein-1 (MCP1)

Subject Area

Internal Medicine

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