Prognostic value of liver fatty acid-binding protein (FABPs) for impairment of renal function in type2 diabetic (T2D) patients

Authors

Hamada Abd El-Lateef, Internal Medicine, Faculty of Medicine, Al-Azhar UniversityFollow
Ayman abd el-rahman, Assistant professor of Internal Medicine Faculty of Medicine, Al- Azhar University- AssuitFollow
mohamed Abo El-Fotouh, Assistant professor of Biochemistery Faculty of Medicine, Al- Azhar University- AssuitFollow
Mohamed Nusseir, Assistant professor of internal medicine, faculty of medicine al-azhar university, assuitFollow
hosny younes, Professor of Internal Medicine Department Faculty of Medicine, Al- Azhar University- AssuitFollow

Corresponding Author

Abd El-Lateef, Hamada

Document Type

Original Article

Abstract

Background - Diabetic microvascular disease is present mainly as retinopathy, nephropathy, neuropathy and vascular abnormalities in the lower extremities, leading to visual impairment, kidney failure, stroke, diabetic cardiomyopathy, and lower extremity dysfunction, respectively. Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein (ILBP) family which plays an important role in the pathogenesis of diabetic nephropathy and chronic kidney diseases. Aim - to evaluate Urinary liver-type fatty acid-binding protein (u-LFABP) biomarker for the occurrence and development of nephropathy in diabetic patients with and without renal disease. Patients and Methods - In this cross sectional study 100 patients were enrolled divided into three groups; Control Group; included 40 normal healthy individuals; Early Diabetic Nephropathy Group (Early-DN); included 30 patients of Type II diabetes and Diabetic Kidney Disease Group (DKD) 30 patients of type II diabetes, all groups evaluated u-LFABP biomarker using ELISA technique. Results - Our results revealed that u-LFABP level was highly significant increased (P<0.001) in early DN group and in DKD patients compared to normal control indicating tubular damage. The levels of u- LFABP increased gradually with declining renal function and reduced e-GFR Conclusion - u-LFABP tubular markers are good predictive factors for DN and DKD characterized with high diagnostic performance. Considering the urinary protein, creatinin, eGFR and provided the high diagnostic information for diagnosing DN. u-LFABP considered as tubular factor that represents kidney state of diabetic patients. It could be used as sensitive marker in predicting progression of DKD than proteinuria in Type 2 diabetes mellitus patients.

Keywords

Diabetes kidney disease; diabetic nephropathy; Fatty acid-binding proteins; Type 2 diabetes mellitus; Urinary liver-type fatty acid-binding protein

How to Cite This Article

Abd El-Lateef, Hamada; abd el-rahman, Ayman; Abo El-Fotouh, mohamed; Nusseir, Mohamed; and younes, hosny (2022) "Prognostic value of liver fatty acid-binding protein (FABPs) for impairment of renal function in type2 diabetic (T2D) patients," Al-Azhar International Medical Journal: Vol. 3: Iss. 11, Article 18.
DOI: https://doi.org/10.21608/aimj.2022.146638.2013