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Corresponding Author

Ayman Ahmed Moawad

Abstract

Background: Colonoscopy induces considerable discomfort and anxiety. Administration of a single anesthetic agent may result in insufficient sedation and pain relief, leading to excessive drug consumption and an escalation in unwanted side effects.

Aim: The study's objective effectiveness of the propofol-fentanyl and propofol-dexmedetomidine combinations in patients having colonoscopy .

Method: colonoscopy patients prospective, randomized, double-blinded, controlled trial conducted on 66 patients undergoing elective colonoscopy. Patients were assigned randomly into two equal groups. Group 1 received Fentanyl 1 µ/kg, combined with propofol 2 mg/kg bolus dose and 9 - 12 mg/kg/hr maintenance in the first 15 minutes, then propofol 6 - 9 mg/kg/hr for the remaining procedure. Group 2 received dexmedetomidine one µ/kg and propofol at the same regimen as group 1.

Results: Dexmedetomidine had a more speedy recovery from anesthesia than fentanyl. After 5 minutes in the PACU, all individuals in the dexmedetomidine group exhibited a modified aldrete score (MAS) of 9, while the median MAS in the fentanyl group was 7 (P=0.001). Oxygen saturation was significantly higher in dexmedetomidine than in fentanyl (97.6% vs. 94.7%). Severe bradycardia and hypotension were not reported in the two groups. No difference was reported regarding the analgesic efficacy, complications, and satisfaction. Nausea was less frequent with dexmedetomidine.

Conclusion: The combination of dexmedetomidine and propofol provided more appropriate analgesia and sedation results with a higher quality of recovery compared to fentanyl and propofol for colonoscopy.

Article Type

Original Article

Keywords

Colonoscopy, Dexmedetomidine, Fentanyl, Propofol, Sedation

Subject Area

Anesthesiology

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