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Abstract

Background: The noninvasive technique known as myocardial perfusion imaging is used to assess the functional relevance of borderline coronary artery abnormalities. Additionally, well-validated intrusive technique known as instantaneous wave-free ratio is employed for same objective, Aim and objectives; to compare perfusion imaging SPECT as a one of the commonly used noninvasive test in assessment of myocardial ischemia &instantaneous wave free ratio as one of the new invasive tools in evaluation of significance of moderate coronary artery disease lesion, Subjects & techniques; This is prospective research, conducted on 50 studied cases who were diagnosed as ischemic heart disease and admitted to National Heart Institute and Al-Azhar University hospitals. Those patients were subjected to coronary angiography that showed moderate lesion (angiographically) in a single vessel then patients who have IFR result between 0.8-0.9 were scheduled to MPI (SPECT) to assess the significance of this border line lesion within 2 weeks of coronary angiography, Result; There were 22 (44%) with positive IFR and the mean value of IFR was 0.88 (±0.08 SD) with range (0.75-1.04), Conclusion; both MPI SPECT&IFR found great sensitivity (90.9%), specificity(96.4%), NPV(93.1%), &PPV(95.2). So, instantaneous wave-free ratio can be valid alternative to fractional flow reserve to evaluate functional significance of intermediate coronary lesions without using agents to induce maximal hyperemia.

Article Type

Original Article

Keywords

Instantaneous wave-free ratio, myocardial perfusion imaging, and coronary artery lesion.

Subject Area

Cardiology

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