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Document Type

Original Article

Abstract

Background: Myocardial necrosis improved while cardiac biomarkers were reduced among individuals with NSTEMI, which was identified as the lack of ST-segment elevation. Myocardial ischemia at rest or during mild activity without cardiac myocyte necrosis characterizes unstable angina. Myocardial ischemia is characterized by an increase in the soluble form of ST2 and the inflammatory cytokine IL-1β in cardiac myocytes. Aim of work: The goal of this study was to asses and determine whether or not serum ST2 levels were predictive of six-month mortality in cases with non-ST segment elevation ACS (by comparing plasma ST2 levels among survivors and non-survivors of NSTE-ACS emergency department diagnoses). Subjects & methods: The research is a prospective cross-sectional observational study that involved 50 participants who presented to the specialized Damietta Cardiac Centre with symptoms and signs of NSTE-ACS within the time period of February 2022 to November 2022. Result: High prevalence of serum ST2 levels was found in patients presenting with NSTEMI more than in patients presenting with unstable angina. The connection between Serum ST2 levels and the short-term outcome was statistically significant. The correlation among Serum ST2 levels and dyspnea was statistically significant. Serum ST2 levels had a significant association with arrhythmias. High levels of Serum ST2 were linked to hospital readmission in a statistically meaningful way. The correlation among Serum ST2 concentrations and coronary artery disease detected by angiography was statistically significant. High ST2 levels were more predictive of mortality and rehospitalization, Dyspnea, Arrhythmias, and obstructive coronary artery disease on ROC curve analysis. Conclusion: In the current investigation, individuals who died within 6 months had higher ST2 values. ST2 cutoff value of 150 ng/mL was determined to have a sensitivity of 97.2% and specificity of 91.3%. In conclusion, serum ST2 levels are positively correlated with 6-month mortality in NSTE-ACS patients. Our research results need to be confirmed by other investigations.

Keywords

serum ST2; non-ST segment; coronary syndrome.

Subject Area

Cardiovascular

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