The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

Authors

Hany Ali, Department of Clinical Pathology, Al-Azhar University, Cairo, EgyptFollow
Rabab Mohamed, Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, EgyptFollow
Samia Hassan, Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, EgyptFollow
Enas A. Ablelaleem Ablelaleem, Department of Rheumatology and Rehabilitation, Faculty of Medicine, Beni-Suef University, Beni-Suef, EgyptFollow
Rabab Bakry, Department of Rheumatology and Rehabilitation, Faculty of Medicine, Beni-Suef University, Beni-Suef, EgyptFollow

Corresponding Author

Ali, Hany

Document Type

Original Article

Abstract

Abstract: Background: SLE is a chronic autoimmune illness in which numerous variables, including epigenetic, genetic, and environmental factors, interact to determine disease risk. The role of the VEGF single nucleotide polymorphism (SNP) in SLE patients was assessed in the current study.Aim of The Work:TO determine whether the vascular endothelial growth factor (VEGF) 1154G/A single nucleotide polymorphism (SNP) is associated with systemic lupus erythematosus (SLE) risk & disease activity. Patients and methods: The study included 50 SLE patients and 50 healthy controls. Full clinical assessment and laboratory investigations were done for the SLE patients. For both patients and controls, the (VEGF) 1154G/A SNP was detected using real-time PCR. Systemic Lupus International Collaborating Clinics Damage Index (SLICC DI) and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were assessed for SLE patients. Results: the minor A allele of VEGFA (1154G/A) SNP was significantly higher in SLE patients with lower SLICC when compared to the healthy subjects (p-value 0.033). Conclusion: According to the findings, the A allele of VEGFA (rs1570360) SNP may protect against SLE and be linked to a better clinical outcome.

Keywords

VEGF; RT-PCR; Gene polymorphism

How to Cite This Article

Ali, Hany; Mohamed, Rabab; Hassan, Samia; Ablelaleem, Enas A. Ablelaleem; and Bakry, Rabab (2022) "The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.," Al-Azhar International Medical Journal: Vol. 3: Iss. 9, Article 9.
DOI: https://doi.org/10.21608/aimj.2022.153427.2059